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MilliporeSigma™ Calbiochem™ RIP1 Inhibitor II, 7-Cl-O-Nec-1

Catalog No. 5042970001
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5042970001 10mg
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Catalog No. 5042970001 Supplier MilliporeSigma™ Supplier No. 5.04297.0001
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Description

RIP1 Inhibitor II, 7-Cl-O-Nec-1, CAS 852391-15-2, is a cell-permeable, highly selective RIP1 inhibitor. Blocks RIP1-dependent necroptosis (EC50 = 206nM in Jurkat cells).

A cell-permeable 7-chloroindolylmethyl-hydantoin that exhibits highly RIP1-selective inhibitory activity among >400 human kinases and is superior to its structural analog Necrostatin-1 (Cat. No. 480065) in blocking RIP1-dependent necroptosis due to improved potency (EC50 = 206nM vs. 494nM with Nec-1 for protecting FADD-deficient Jurkat from 30 h 10 ng/mL TNF-α-induced death), selectivity, metabolic stability, as well as reduced in vitro and in vivo toxicity. Reported to be blood-brain barrier permeable in mice and be efficacious in reducing brain infarct size when applied via intracerebroventricular injections in a murine MCAO model in vivo (8 nmol/2μL/mouse).

Specifications

Color Yellow
Description 96% by HPLC
Target Proteins RIP1
Molecular Formula C13H12ClN3O2
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg