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MilliporeSigma™ Calbiochem™ Rho Inhibitor, Rhosin

Catalog No. 55546025MG
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25 mg
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55546025MG 25 mg
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Catalog No. 55546025MG Supplier MilliporeSigma™ Supplier No. 55546025MG
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Description

Rho Inhibitor, Rhosin, CAS 1173671-63-0, is a cell-permeable compound that directly targets Rho GEF binding domain (Kd = 354nM for RhoA), thereby prevents Rho from interacting with its GEFs.

A cell-permeable (quinoxalinylmethylidene-D-Tryptophanyl)hydrazide that directly targets Rho GEF binding domain (Kd = 354nM for RhoA), thereby prevents Rho from interacting with its GEFs (including LARG, DBL, LBC, p115 RhoGEF, and PDZ RhoGEF), but not p190RhoGAP, RhoGDI, or its effectors (ROCK, mDia, PKN, Rhoteckin). Shown to inhibit serum-induced RhoA, RhoB, and RhoC, but not Cdc42 or Rac1, activation, MLC & PAK phosphorylation, as well as stress fiber & focal complex formation in serum-starved NIH3T3 cultures (Effective conc. 30μM) in a reversible manner.

Specifications

Color Orange Brown
Description 93% by HPLC
Target Proteins Rho GTPase
Molecular Formula C20H18N6O
Formula Weight 358.4g/mol
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 25 mg