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MilliporeSigma™ Calbiochem™ InSolution™ Y-27632 in DMSO

Catalog No. 6880021MG
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6880021MG 1 mg
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Catalog No. 6880021MG Supplier MilliporeSigma™ Supplier No. 6880021MG
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Description

InSolution™ Y-27632 is a 10mm solution in DMSO. A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140nM for p160ROCK).

A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (∽100μM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. A 5mm (500μg/296μl) solution of Y-27632 (Cat. No. 688001) in H2O and the solid form of this compound (Cat. No. 688000) are also available.

Specifications

Formulation A 10 mM (1mg/296μl) solution of Y-27632 in DMSO.
Description 95% by HPLC
Molecular Formula C14H21N3O·2HCl·H2O
Formula Weight 338.3g/mol
Content And Storage Avoid Freeze-Thaw Cycles, Hygroscopic, Protect from Light
Form Liquid
Quantity 1 mg