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MilliporeSigma™ Calbiochem™ Cisplatin

Catalog No. 23212050MG
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23212050MG 50 mg
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Catalog No. 23212050MG Supplier MilliporeSigma™ Supplier No. 23212050MG

Description

Reported to sensitize glioma cells to TNF-α-induced apoptosis.

A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154mm NaCl with or without 10mg/mL mannitol) or PBS (with 140mm NaCl) is recommended for solubilization prior to culture treatment.

Specifications

Color Yellow
Description 98% by HPLC
Target Proteins Induces apoptosis in cancer cells
CAS 15663-27-1
Molecular Formula Pt(NH3)2Cl2
Formula Weight 300g/mol
Solubility DMSO, H2O with 154 mM NaCl, or PBS with 140 mM NaCl
Form Solid
Quantity 50 mg