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MilliporeSigma™ Calbiochem™ Bortezomib

Catalog No. 5043140001
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5043140001 5mg
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Catalog No. 5043140001 Supplier MilliporeSigma™ Supplier No. 5.04314.0001
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Description

Bortezomib, CAS 179324-69-7, is a cell-permeable, selective, slowly reversible inhibitor of 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- and β2 TL/trypsin-like activity.

A cell-permeable dipeptidylboronate compound that selectively inhibits 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- and β2 TL/trypsin-like activity ( k inact/ K i = 38,000, 5,700, and <100 M-1s-1, respectively, in human 20S proteasome assays using 10μM Suc-LLVY-AMC/Cat. No. 539142, 10μM Z-LLE-AMC/Cat. No. 539141, or 50μM Boc-LRR-AMC as substrate) via a covalent, slowly reversible manner, displaying much reduced potency against human chymotrypsin, cathepsin G, leukocyte elastase, and thrombin (Ki = 0.32, 0.63, 2.3, and 13μM, respectively, vs. 620nM using rabbit muscle 20S). A widely used inhibitor both in cultures in vitro and in animals in vivo .

Specifications

Color Off-white
Description 99% by HPLC
Target Proteins 20S proteasome
Molecular Formula C19H25BN4O4
Formula Weight 384.2g/mol
Solubility DMSO or EtOH
Content And Storage Hygroscopic, Protect from light
Form Solid
Quantity 5 mg