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  6. MilliporeSigma™ Calbiochem™ Cyclopamine, V. californicum

MilliporeSigma™ Calbiochem™ Cyclopamine, V. californicum

Catalog No. 2398031MG
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2398031MG 1 mg
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Catalog No. 2398031MG Supplier MilliporeSigma™ Supplier No. 2398031MG
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Description

Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog signaling through direct interaction with Smo.

A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. Also available as a 10mm solution in Ethanol (Cat. No. 239806).

Specifications

Color Off-white
Target Proteins Hh signaling in Shh-light2 assay
CAS 4449-51-8
Molecular Formula C27H41NO2
Formula Weight 411.6g/mol
Solubility DMSO, EtOH, or DMF
Content And Storage Protect from light
Form Solid
Quantity 1 mg
Purity 97% by HPLC