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Berberine chloride

Catalog No. AAJ6231106
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AAJ6231106 5 g
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Catalog No. AAJ6231106 Supplier Thermo Scientific Chemicals Supplier No. J6231106
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Description

CAS: 633-65-8 | C20H18ClNO4 | 371.817 g/mol

Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in dimethyl sulfoxide (74 mg/ml at 25°C), ethanol (<1mg/mL at 25°C), water (<1mg/mL at 25°C), and methanol.

Notes
Store at -20°C. Incompatible with oxidizing agents. Protect from heat.

Chemical Identifiers

CAS 633-65-8
Molecular Formula C20H18ClNO4
Molecular Weight (g/mol) 371.817
MDL Number MFCD00011939
InChI Key VKJGBAJNNALVAV-UHFFFAOYSA-M
Synonym berberine chloride, berberine hydrochloride, natural yellow 18, benzodioxide, berberinium chloride, berberine hcl, unii-uot4o1byv8, berberine chloride jan, uot4o1byv8
PubChem CID 12456
ChEBI CHEBI:31271
SMILES COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]

Specifications

Color Yellow to Orange
Quantity 5 g
Beilstein 3836585
Solubility Information Soluble in dimethyl sulfoxide (74mg/ml at 25°C),ethanol (<1mg/ml at 25°C),water (<1mg/ml at 25°C),and methanol.
Formula Weight 371.82
Physical Form Powder
Chemical Name or Material Berberine chloride

Safety and Handling

EINECSNumber 211-195-9
TSCA Yes
Recommended Storage Keep cold

RUO – Research Use Only