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Promega ADCC Bioassay Effector Cells, Propagation Model 
Allows propagation and banking of the ADCC Bioassay Effector Cells. Product includes two frozen vials of Bio-Glo™ Luciferase Assay System reagent at 2 x 107 cells/mL and 0.65mL/vial. One vial should be used to create a cell bank, and the other should be reserved as backup.
Supplier: Promega G7102
Description
Fc receptor-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action (MOA) by which antibodies target disease cells for elimination. Classic methods used to measure ADCC utilize primary donor peripheral blood mononuclear cells (PBMCs) or purified natural killer (NK) cells that express Fc receptors on their cell surface.
Following engagement with the Fc region of a relevant antibody bound to a target disease cell, Fc receptors transduce intracellular signals within the effector cell resulting in elimination of the target cell. These primary cell-based assays are highly variable as a result of donor differences and the requirement for cell culture and expansion.
Specifications
| Store below -140°C (freezer or liquid nitrogen vapor phase) | |
| 2 x 1.0 mL | |
| Allows Propagation and Banking of the ADCC Bioassay, V Variant, Effector Cells | |
| ADCC Bioassay Effector Cells (CPM) |