missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. PRG7102

Promega ADCC Bioassay Effector Cells, Propagation Model

Catalog No. PRG7102
Encompass
Change view
Click to view available options
Quantity:
2 x 1.0 mL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PRG7102 2 x 1.0 mL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PRG7102 Supplier Promega Supplier No. G7102

Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.

Description

Allows propagation and banking of the ADCC Bioassay Effector Cells. Product includes two frozen vials of Bio-Glo™ Luciferase Assay System reagent at 2 x 107 cells/mL and 0.65mL/vial. One vial should be used to create a cell bank, and the other should be reserved as backup.

Fc receptor-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action (MOA) by which antibodies target disease cells for elimination. Classic methods used to measure ADCC utilize primary donor peripheral blood mononuclear cells (PBMCs) or purified natural killer (NK) cells that express Fc receptors on their cell surface.

Following engagement with the Fc region of a relevant antibody bound to a target disease cell, Fc receptors transduce intracellular signals within the effector cell resulting in elimination of the target cell. These primary cell-based assays are highly variable as a result of donor differences and the requirement for cell culture and expansion.

Specifications

Quantity 2 x 1.0 mL
Content And Storage Store below -140°C (freezer or liquid nitrogen vapor phase)
For Use With (Application) Allows Propagation and Banking of the ADCC Bioassay, V Variant, Effector Cells
Product Type ADCC Bioassay Effector Cells (CPM)