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Tocris Bioscience™ A 33

Catalog No. 631310
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631310 10 mg
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Catalog No. 631310 Supplier Tocris Bioscience™ Supplier No. 6313/10
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Description

Potent and selective PDE4B inhibitor

A 33 is a potent and selective PDE4B inhibitor (IC50 = 15 nM); exhibits >100-fold selectivity for PDE4B over 4D. Regulates cAMP in inflammatory cells. Inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. Reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. Also exhibits antidepressant-like effects. Orally bioavailable.

Specifications

Chemical Name or Material 2-[4-[[2-(5-Chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]acetic acid
CAS 915082-52-9
Quantity 10 mg
Molecular Formula C19H18ClN3O2S
Formula Weight 387.88
Product Type Inhibitor
Purity 98%