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4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97%

Catalog No. AAH26473MD
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250 mg
1 g
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AAH26473MD 250 mg
AAH2647303 1 g
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Catalog No. AAH26473MD Supplier Thermo Scientific Chemicals Supplier No. H26473MD
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Description

CAS: 30827-99-7 | C8H11ClFNO2S | 239.689 g/mol

AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

Solubility
Soluble in water 50 mg/mL or 100% ethanol.

Notes
Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, air, moisture.

Chemical Identifiers

CAS 30827-99-7
Molecular Formula C8H11ClFNO2S
Molecular Weight (g/mol) 239.689
MDL Number MFCD00132962
InChI Key WRDABNWSWOHGMS-UHFFFAOYSA-N
Synonym 4-2-aminoethyl benzenesulfonyl fluoride hydrochloride, aebsf, aebsf hydrochloride, pefabloc sc, aebsf hcl, pefabloc, 4-2-aminoethyl benzene-1-sulfonyl fluoride hydrochloride, aebsf, hydrochloride, benzenesulfonyl fluoride, 4-2-aminoethyl-, hydrochloride, 4-2-aminoethyl benzenesulfonylfluoride hydrochloride
PubChem CID 186136
IUPAC Name 4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride
SMILES C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl

Specifications

Melting Point ∼184°C (decomposition)
Quantity 250 mg
UN Number UN3261
Beilstein 7604627
Sensitivity Moisture sensitive
Solubility Information Soluble in water 50mg/mL or 100% ethanol.
Formula Weight 239.69
Percent Purity 97%
Chemical Name or Material 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride

Safety and Handling

Hazard Category H314-H500
Hazard Statement GHS H Statement
H314-H318
Causes severe skin burns and eye damage.
Causes serious eye damage.
Precautionary Statement P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
DOTInformation Hazard Class: 8; Packaging Group: III
TSCA No
Recommended Storage Store at -20°C

RUO – Research Use Only