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Alfa Aesar™ 3-(4-Fluorobenzoyl)propionic acid, 97%

$34.95 - $138.85

Chemical Identifiers

Chemical Name or Material 3-(4-Fluorobenzoyl)propionic acid
CAS 366-77-8
Molecular Formula C10H9FO3
Formula Weight 196.18
MDL Number MFCD00002793
Beilstein 958145
View More Specs
Products
Catalog Number Mfr. No. Packaging Quantity Price Quantity    

AAA1375506

  SDS
alfa aesar™
A1375506
Each for $34.95

AAA1375514

  SDS
alfa aesar™
A1375514
Each for $138.85
Description & Specifications

Specifications

Formula Weight 196.18
Chemical Name or Material 3-(4-Fluorobenzoyl)propionic acid
Assay 97%
Molecular Formula C10H9FO3
MDL Number MFCD00002793
CAS 366-77-8
Beilstein 958145
Health Hazard 1 Warning
Health Hazard 2 GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Health Hazard 3 GHS P Statement
P280g-P305+P351+P338
Wear protective gloves.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Odor Odorless
Melting Point 99° to 103°C
Quantity 5g

Applications
7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone.

Solubility
Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Safety and Handling

Warning

GHS P Statement
P280g-P305+P351+P338
Wear protective gloves.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.