Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
The nuclear hormone receptor gene family includes receptors for thyroid and steroid hormones, retinoids and vitamin D, as well as receptors of unknown ligands.
DNA surveillance proteins monitor DNA integrity, and they can activate cell cycle checkpoints and DNA repair pathways in response to DNA damage. This can prevent potentially deleterious mutations.
The Silencer™ Select Human Drug Targets siRNA Library contains 23,778 Ambion™ Silencer Select highly potent and chemically-modified siRNAs targeting 7,926 genes for performing RNAi screens against known human drug target genes.
The Silencer™ Human Apoptosis siRNA Library provides investigators with a focused siRNA screening platform targeting apoptosis genes and enabling a detailed analysis of the apoptotic signaling pathway.
The Silencer™ Select Human Epigenetics siRNA Library contains 1563 Ambion™ Silencer Select highly potent, chemically-modified siRNAs targeting 521 epigenetic enzymes, including those mediating epigenetic signaling through the acetylation and methylation of histones.
Ion channels are key components in a multitude of biological processes, including rapid changes in muscle cell contractions, epithelial transport of nutrients and ions, T cell activation and pancreatic beta-cell insulin release.