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Tocris Bioscience™ WS 6

Catalog No. 361063891
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10 mg
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Catalog No. Quantity
361063891 10 mg
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Catalog No. 361063891 Supplier Tocris Bioscience™ Supplier No. 7791/10
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Description

Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons

WS 6 induces growth and proliferation of cultured islet α and β cells in vitro (EC50 = 0.28 μM at β cells). Inhibits growth of FLT3-ITD+ AmL and K562 CmL cells (IC50 values are <0.24 nM and 40.48 nM, respectively). Reduces blood glucose in an animal model of type 1 diabetes. In combination with TTNPB (Cat. No. 0761) and 1-azakenpaullone, WS 6 induces and maintains murine totipotent stem cells. In an animal model of depression WS 6 induces dendrite complexity, enhances hippocampal neurogenesis, increases GABAergic neurons and GABA expression, and displays antidepressant and anxiolytic activity. WS 6 is predicted to be a receptor tyrosine kinase inhibitor.

Specifications

Chemical Name or Material 4-[[6-[(Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzeneacetamide
CAS 1421227-53-3
Quantity 10 mg
Target Compounds for Stem Cell Proliferation and Renewal
Molecular Formula C29H31F3N6O3
Purity 98%