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  5. Tocris Bioscience™ VCP 171

Tocris Bioscience™ VCP 171

Catalog No. 626150
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626150 50 mg
626110 10 mg
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Catalog No. 626150 Supplier Tocris Bioscience™ Supplier No. 6261/50

Description

Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist

VCP 171 is an adenosine A1 receptor positive allosteric modulator (PAM) (pKB = 5.65, binding cooperativity with NECA 0.68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor-mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve-injury model of neuropathic pain.

Specifications

Chemical Name or Material [2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone
CAS 1018830-99-3
Quantity 50 mg
Target Adenosine A1 Receptor Modulators
Molecular Formula C18H12F3NOS
Purity 0.98