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Tocris Bioscience™ Vandetanib

Catalog No. 749710
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749710 10 mg
749750 50 mg
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Catalog No. 749710 Supplier Tocris Bioscience™ Supplier No. 7497/10

Description

Potent VEGFR-2 inhibitor, also inhibits EGFR and RET oncoproteins activity

Vandetanib is a potent VEGFR-2 inhibitor (IC50 = 0.04 μM), and inhibitor of EGFR (IC50 = 0.5 μM). Vandetanib potently inhibits (IC50 = 100 nM) RET oncoprotein activity in human thyroid cancer. Vandetanib displays anti-angiogenic properties in human nasopharyngeal carcinoma in mice model. Vandetanib is orally available and effective in vivo.

Specifications

Chemical Name or Material N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
CAS 443913-73-3
Quantity 10 mg
Target VEGF Receptor Inhibitors
Molecular Formula C22H24BrFN4O2
Purity 0.98