Invitrogen™ Thyroglobulin Monoclonal Antibody (TG60), Invitrogen™

Description

MA1-10593 detects Thyroglobulin, specifically both T3 and T4, from human samples. MA1-10593 has been successfully used in ELISA applications. The MA1-10593 immunogen is purified human Thyroglobulin.

The human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti-thyroglobulin autoantibodies were the first factor to be discovered. Anti-hTG is found in all thyroid autoimmune diseases (Hashimoto thyroiditis, Graves diseases), with the highest level observed in Hashimoto thyroiditis. Anti-hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.