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Tocris Bioscience™ Thalidomide-4-hydroxyacetate

Catalog No. 6466100
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Catalog No. Quantity
6466100 100 mg
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Catalog No. 6466100 Supplier Tocris Bioscience™ Supplier No. 6466/100

Description

Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs

Thalidomide-4-hydroxyacetate is a derivative of Thalidomide (Cat.No. 0652), commonly used as a precursor to PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.

Thalidomide-4-hydroxyacetate has been recently renamed. The previous name for this product was TC E3 5031.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch .

Specifications

CAS 1061605-21-7
Synonym 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid
Quantity 100 mg
Target Degrader Building Blocks
Molecular Formula C15H12N2O7
Formula Weight 332.26
Purity 98%