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Tamibarotene
A retinoic acid receptor → (RAR→) agonist | CAS: 94497-51-5 | C22H25NO3 | 351.45 g/mol
$293.04 - $1071.53
Identifiants chimiques
| CAS | 94497-51-5 |
|---|---|
| Molecular Formula | C22H25NO3 |
| Molecular Weight (g/mol) | 351.45 |
| MDL Number | MFCD00866188 |
| InChI Key | MUTNCGKQJGXKEM-UHFFFAOYSA-N |
| Synonym | tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202 |
| PubChem CID | 108143 |
| ChEBI | CHEBI:32181 |
| IUPAC Name | 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid |
| SMILES | CC1(C)CCC(C)(C)C2=CC(NC(=O)C3=CC=C(C=C3)C(O)=O)=CC=C12 |
| Numéro de catalogue | Numéro du manufacturier. | Quantity | Prix | Quantité | |||||
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| Numéro de catalogue | Numéro du manufacturier. | Quantity | Prix | Quantité | |||||
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AAJ64028MA
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Thermo Scientific Chemicals
J64028MA |
10 mg |
chaque for $293.04
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Connectez-vous ou enregistrez-vous pour vérifier votre prix et la disponibilité.
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AAJ64028MF
|
Thermo Scientific Chemicals
J64028MF |
50 mg |
chaque for $1,071.53
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|
Connectez-vous ou enregistrez-vous pour vérifier votre prix et la disponibilité.
|
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Description
Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 ?M respectively).
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsTamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively).
Solubility
Soluble to 50 mM in DMSO
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
Identifiants chimiques
| 94497-51-5 | |
| 351.45 | |
| MUTNCGKQJGXKEM-UHFFFAOYSA-N | |
| 108143 | |
| 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid |
| C22H25NO3 | |
| MFCD00866188 | |
| tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202 | |
| CHEBI:32181 | |
| CC1(C)CCC(C)(C)C2=CC(NC(=O)C3=CC=C(C=C3)C(O)=O)=CC=C12 |
Spécifications
| 94497-51-5 | |
| C22H25NO3 | |
| 10 mg | |
| tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202 | |
| MUTNCGKQJGXKEM-UHFFFAOYSA-N | |
| 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid | |
| 108143 | |
| 351.44 | |
| Tamibarotene |
| White | |
| MFCD00866188 | |
| 14,9047 | |
| Soluble to 50 mM in DMSO | |
| CC1(C)CCC(C)(C)C2=CC(NC(=O)C3=CC=C(C=C3)C(O)=O)=CC=C12 | |
| 351.45 | |
| CHEBI:32181 | |
| Solid |
Sécurité et manipulation
missing translation for 'rtecsNumber' : DH6940000
missing translation for 'tsca' : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only