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Tamibarotene

Catalog No. p-7042860
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AAJ64028MA 10 mg
AAJ64028MF 50 mg
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Catalog No. AAJ64028MA Supplier Thermo Scientific Chemicals Supplier No. J64028MA
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Description

A retinoic acid receptor → (RAR→) agonist | CAS: 94497-51-5 | C22H25NO3 | 351.45 g/mol

Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 ?M respectively).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively).

Solubility
Soluble to 50 mM in DMSO

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.

Chemical Identifiers

CAS 94497-51-5
Molecular Formula C22H25NO3
Molecular Weight (g/mol) 351.45
MDL Number MFCD00866188
InChI Key MUTNCGKQJGXKEM-UHFFFAOYSA-N
Synonym tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202
PubChem CID 108143
ChEBI CHEBI:32181
IUPAC Name 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
SMILES CC1(C)CCC(C)(C)C2=CC(NC(=O)C3=CC=C(C=C3)C(O)=O)=CC=C12

Specifications

Color White
Quantity 10 mg
Merck Index 14,9047
Solubility Information Soluble to 50 mM in DMSO
Formula Weight 351.44
Physical Form Solid
Chemical Name or Material Tamibarotene

Safety and Handling

RTECSNumber DH6940000
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only