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  6. Thermo Scientific™ SurePac™ Oligo RP MDi™ HPLC Columns

Thermo Scientific™ SurePac™ Oligo RP MDi™ HPLC Columns

Numéro de catalogue. 43712102132
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Diamètre (métrique):
2.1 mm
300 μm
Longueur (métrique):
20 mm
50 mm
100 mm
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Numéro de catalogue. Diamètre (métrique) Longueur (métrique)
43712102132 2.1 mm 100 mm
43712022132 2.1 mm 20 mm
43712052132 2.1 mm 50 mm
43712050332 300 μm 50 mm
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Numéro de catalogue. 43712102132 Fournisseur Thermo Scientific™ Code fournisseur 43712102132

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Description

SurePac Oligo RP MDI is a robust reversed-phase column designed for oligonucleotide analysis by HPLC and LC-MS. It delivers high recovery, bioinert column hardware, and reproducible separations, enabling reliable profiling of oligonucleotides of any size.

Thermo Scientific™ SurePac™ Oligo RP MDi™ HPLC columns deliver high-resolution, reproducible separations for therapeutic oligonucleotides and nucleic acids across R and D and QC workflows. Built on monodisperse, supermacroporous polymeric packing with bio-inert hardware, they provide stable performance even under elevated pH and temperature conditions, resolving truncation impurities while supporting large oligos and intact nucleic acids for scalable LC-MS and LC-UV analysis.

  • Purpose-built for oligonucleotide RP separations
  • Optimized for DNA and RNA oligonucleotides, including modified sequences, delivering consistent retention and selectivity across short and long oligos.
  • Bioinert, metal-free fluid path
  • Reduces metal/oligonucleotide interactions to improve recovery, minimize adsorption, and deliver cleaner peak shapes for sensitive analyses.
  • Optimized for ion-pair RP LC-MS
  • Fully compatible with common ion-pairing reagents such as HFIP/TEA, enabling sensitive, reproducible LC-MS detection.
  • High recovery of long and modified oligonucleotides
  • High resolution power for oligonucleotides spanning over a wide size range from small to (ultra) large
  • Supports efficient analysis of long, hydrophobic, and chemically complex oligos without compromising signal or resolution.
  • Robust stationary phase for demanding methods
  • Maintains stable performance under high organic content and elevated temperatures, supporting fast gradients and long column lifetimes.
  • Excellent peak shape and impurity resolution
  • Delivers sharp, symmetrical peaks and reliable separation of closely related species, including impurities and sequence variants.
  • Reproducible, manufacturing-controlled performance
  • Ensures consistent results across columns and batches, simplifying method transfer and routine use.
  • Flexible for development and routine workflows
  • Suitable for method development, impurity profiling, and QC, reducing the need for multiple column chemistries.
  • Compatible with UHPLC and HPLC systems
  • Designed for seamless integration into modern LC platforms and existing laboratory setups.
  • Built for confident bioanalytical results
  • Improves robustness, reduces variability, and supports reliable data generation in oligonucleotide workflows.

Spécifications

Format de la colonne Analytical
Diamètre (métrique) 2.1 mm
Débit 0.2 to 0.6 mL/min.
Longueur (métrique) 100 mm
Pression maximale 6500 psi (448 bar)
Granulométrie 2.5 μm
pH 2 to 12
Taille des pores Proprietary supermacroporous
Température 5°C to 90°C
Phase stationnaire Poly-DVB
Matériau de remplissage Polymeric
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