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  5. Tocris Bioscience™ SMIP 004

Tocris Bioscience™ SMIP 004

Catalog No. 719250
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719250 50 mg
719210 10 mg
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Catalog No. 719250 Supplier Tocris Bioscience™ Supplier No. 7192/50
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Description

SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase

SMIP 004 is a SKP2 (S-phase kinase-associated protein 2) inhibitor. Upregulates p27 and activates the unfolded protein response (UPR) in LNCaP prostate cancer cells overexpressing SKP2. Also induces oxidative stress. Induces proteasomal degradation of cyclin D1 and acts as CDK2 inhibitor. Arrests cell cycle in G1 phase and induces apoptosis in prostate cancer cells, but not normal cells in vitro. Inhibits growth of breast and prostate cancer xenografts in mice. Also induces autophagy and reduces replication of MERS-CoV in VeroB4 cells.

Specifications

Chemical Name or Material N-(4-Butyl-2-methylphenyl)acetamide
CAS 143360-00-3
Quantity 50 mg
Target Ubiquitin Ligase (E3) Inhibitors
Molecular Formula C13H19NO
Purity 0.98