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Tocris Bioscience™ Ribavirin
Description
Antiviral guanosine ribonucleoside analog; misincorporated into mRNA by viral-dependent RNA polymerases. Binds to and redistributes mammalian eIF4E from the nucleus to the cytoplasm (Ki ∽ 0.3 μM for the active metabolite, ribavirin triphosphate). Also inosine monophosphate dehydrogenase (IMPDH) inhibitor. Represses colony formation of primary AML-M5 progenitor cells (IC50 ∽ 1 μM); reduces disease severity in acute myeloid leukemia (AML). Inhibits cytopathic effect of SARS-CoV in Vero cells in vitro. Orally available.
Specifications
Specifications
| Quantity | 50 mg |
| Formula Weight | 244.2 |
| Purity | >99% |
| Molecular Weight (g/mol) | 244.207 |
| Chemical Name or Material | Protein-synthesizing GTPase Compounds |
Safety and Handling
| Recommended Storage | Store at +4°C |