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  5. Tocris Bioscience™ ABT 089 Dihydrochloride

Tocris Bioscience™ ABT 089 Dihydrochloride

Catalog No. 507910R
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50 mg
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Catalog No. Quantity
507910R 10 mg
507950R 50 mg
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Catalog No. 507910R Supplier Tocris Bioscience™ Supplier No. 5079/10

Description

High affinity and selective α4β2 nAChR partial agonist

ABT 089 dihydrochloride is a high affinity and selective α4β2 partial agonist (Ki = 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro. Enhances cognitive performance in vivo. Orally bioavailable and brain penetrant.

Specifications

Chemical Name or Material ABT 089 dihydrochloride
CAS 161416-61-1
Synonym 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride
Quantity 10 mg
Solubility Soluble to 100mM in water and to 20mM in DMSO
Molecular Formula C11H16N2O·2HCl
Formula Weight 265.18
Physical Form Solid
Product Type Bioactive Small Molecule
Purity >98%

Research Use Only. Not For Human or Veterinary Use