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Thermo Scientific™ SPDP (succinimidyl 3-(2-pyridyldithio)propionate)
Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups on 3-atom spacer arm; forms cleavable disulfide bonds with cysteines.
Supplier: Thermo Scientific™ 21857
Description
Thermo Scientific™ Pierce SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.
Highlights:
- Widely used in immunochemistry; conjugates used in drug carrier systems, antibody production and enzyme immunoassays
- Can be used as a protein thiolation reagent
- Reactive groups: NHS ester and pyridyldisulfide
- Reactive toward: amino and sulfhydryl groups
Specifications
| Amine-Sulfhydryl | |
| SPDP | |
| No | |
| Upon receipt store at -20°C protected from moisture. | |
| Ambient | |
| Chemical Labeling | |
| NHS Ester, Pyridyldisulfide | |
| Powder | |
| DMF, DMSO | |
| No |
| By Thiols | |
| 312.36 | |
| 6.8 AÌ | |
| Yes | |
| Pierce™ | |
| Heterobifunctional | |
| Short (<10 AÌ) | |
| 50 mg | |
| Standard, Premium-grade | |
| Crosslinker |
For Research Use Only. Not for use in diagnostic procedures.