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Thermo Scientific™ LC-SMCC (succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate))

Catalog No. pi22362
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50 mg
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Catalog No. Quantity
PI22362 50 mg
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Catalog No. PI22362 Supplier Thermo Scientific™ Supplier No. LSG22362
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Description

Crosslink amines to sulfhydryls with this long crosslinker composed of NHS-ester and maleimide groups at ends of a stabilizing cyclohexane-containing, 15-atom spacer arm.

Thermo Scientific™ Pierce LC-SMCC is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a long cyclohexane-stabilized spacer arm (16.2 Ås)

Highlights:

  • Ideal for coupling enzymes to antibodies as both enzyme activity and antibody specificity can be preserved after coupling
  • Cyclohexane-containing spacer stabilizes the maleimide group
  • Useful for the preparation of stable maleimide-activated proteins
  • Reactive groups: NHS ester and maleimide
  • Reactive toward: amino and sulfhydryl groups

Specifications

Chemical Reactivity Amine-Sulfhydryl
Cleavable No
Description LC-SMCC
Molecular Weight (g/mol) 447.48
PEGylated No
Spacer Arm Length 16.2 Å
Content And Storage Upon receipt store desiccated at 4°C.
Cell Permeability Yes
Shipping Condition Ambient
Product Line Pierce
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety Maleimide, NHS Ester
Spacer Medium (10 to 30 Å)
Form Solid
Quantity 50 mg
Solubility DMF, DMSO
Format Standard
Water Soluble No
Product Type Crosslinker
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For Research Use Only. Not for use in diagnostic procedures.