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Tocris Bioscience™ PF 4708671

Catalog No. 40325
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5 mg
25 mg
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Catalog No. Quantity
40325 5 mg
403225 25 mg
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Catalog No. 40325 Supplier Tocris Bioscience™ Supplier No. 4032/5
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Description

S6K1 inhibitor

PF 4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki = 20 nM; IC50 = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo. Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro.

Specifications

Chemical Name or Material 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole
CAS 1255517-76-0
Assay Percent Range >98%
Quantity 5 mg
Molecular Formula C19H21F3N6
Formula Weight Observed MW: 390.41