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  8. p-Toluenesulfonylmethyl isocyanide, 97%

p-Toluenesulfonylmethyl isocyanide, 97%

Catalog No. p-7021819
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Quantity:
100 g
25 g
5 g
Catalog No. Quantity
AAA1431206 5 g
AAA1431214 25 g
AAA1431222 100 g
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Catalog No. AAA1431206

Supplier: Thermo Scientific Chemicals A1431206

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Description

CAS: 36635-61-7 | C9H9NO2S | 195.24 g/mol

p-Toluenesulfonylmethyl isocyanide is a synthetic reagent used in the synthesis of triplet drugs with the 1,3,5-trioxazatriquinane skeleton, pyrroles, oxazoles and in imidazoles. It serves as an isonitrile component in a diastereoselective Passerini reaction. Furthermore, it is used in the Van Leusen reaction to convert aldehydes to nitriles.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
p-Toluenesulfonylmethyl isocyanide is a synthetic reagent used in the synthesis of triplet drugs with the 1,3,5-trioxazatriquinane skeleton, pyrroles, oxazoles and in imidazoles. It serves as an isonitrile component in a diastereoselective Passerini reaction. Furthermore, it is used in the Van Leusen reaction to convert aldehydes to nitriles.

Solubility
Soluble in chloroform and methanol. Insoluble in water.

Notes
Moisture, air and light sensitive. Store in cool place. Incompatible with strong bases and strong oxidizing agents.

Chemical Identifiers

CAS 36635-61-7
Molecular Formula C9H9NO2S
Molecular Weight (g/mol) 195.24
MDL Number MFCD00000005
InChI Key CFOAUYCPAUGDFF-UHFFFAOYSA-N
Synonym tosylmethyl isocyanide, tosmic, p-toluenesulfonylmethyl isocyanide, 4-toluenesulphonylmethyl isocyanide, 4-toluenesulfonylmethyl isocyanide, tosylmethylisocyanide, 1-isocyanomethylsulfonyl-4-methylbenzene, p-tolylsulfonyl methyl isocyanide, unii-c35fd6olh8, 1-isocyanomethyl sulfonyl-4-methylbenzene
PubChem CID 161915
IUPAC Name 1-(isocyanomethylsulfonyl)-4-methylbenzene
SMILES CC1=CC=C(C=C1)S(=O)(=O)C[N+]#[C-]

Specifications

Melting Point 109°C to 114°C
Quantity 5 g
UN Number UN2811
Beilstein 3592382
Sensitivity Moisture sensitive
Solubility Information Soluble in chloroform and methanol. Insoluble in water.
Formula Weight 195.24
Percent Purity ≥97%
Chemical Name or Material p-Toluenesulfonylmethyl isocyanide

Safety and Handling

Hazard Category H301+H311+H331-H334
Hazard Statement GHS H Statement
H300-H311-H331
Fatal if swallowed.
Toxic in contact with skin.
Toxic if inhaled.
Precautionary Statement P261-P264b-P270-P271-P280-P285-P301+P310-P302+P352-P304+P340-P311-P312-P330-P361-P363-P501c
DOTInformation Transport Hazard Class: 6.1; Packing Group: II; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber 253-140-1
TSCA No
Recommended Storage Ambient temperatures; Store under Nitrogen

RUO – Research Use Only