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Tocris Bioscience™ NX 2127

Catalog No. 89515
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89515 5 mg
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Catalog No. 89515 Supplier Tocris Bioscience™ Supplier No. 8951/5
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Description

Potent BTK Degrader (PROTAC™)

NX 2127 is a potent BTK Degrader (PROTAC®) (DC50 = 4.5 nM and Dmax = 94%). It comprises a BTK binding moiety joined by a linker to a cereblon (CRBN) ligand. NX 2127 also degrades the transcription factors IKZF1 and IKZF3 (DC50 = 57 and 36 nM, respectively). In vivo, NX 2127 possesses potent target degradation activity across species and demonstrates efficacy in preclinical oncology models. NX 2127 is orally bioavailable.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 3-[[4-[1-[[(3R)-1-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-pyrrolidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-(1-piperidinyl)-2-pyrazinecarboxamide
CAS 3024312-52-2
Quantity 5 mg
Target Active Degraders
Molecular Formula C39H45N9O5
Purity 98%