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  5. 54295R

Tocris Bioscience™ NG 25

Numéro de catalogue. 54295R
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Numéro de catalogue. Quantity
54295R 5 mg
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Numéro de catalogue. 54295R Fournisseur Tocris Bioscience™ Code fournisseur 5429/5*
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Description

TGF-β-activated kinase (TAK1) inhibitor

NG 25 is a TGF-β-activated kinase (TAK1) inhibitor (IC50 = 149 nM). Also inhibits LYN, MAP4K2 and Abl kinase activity (IC50 values are 12.9, 21.7 and 75.2 nM, respectively). Suppresses CpG A and CpG B-stimulated secretion of IFN-α and TLR7/8 agonist CL097-stimulated secretion of IFN-β in Gen 2.2 leukemia cells in vitro.

Spécifications

Chemical Name or Material N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
CAS 1315355-93-1
Quantity 5 mg
Target Other Kinase Inhibitors
Molecular Formula C29H30F3N5O2
Formula Weight 537.58
Purity >98%