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Tocris Bioscience™ Neratinib

Catalog No. 737110
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737110 10 mg
737150 50 mg
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Catalog No. 737110 Supplier Tocris Bioscience™ Supplier No. 7371/10
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Description

Potent HER2 receptor tyrosine kinase and EGFR kinase inhibitor

Neratinib is a potent, irreversible inhibitor of HER-2/ErbB2 receptor tyrosine kinase and EGFR kinase (IC50 = 59 nM and 92 nM, respectively). Neratinib reduces receptor autophosphorylation and proliferation of EGFR-dependent cancer cells, blocks cell-cycle progression and inhibits HER-2 signaling pathways. Neratinib suppresses proliferation of gefitinib -resistant non-small cell lung cancer cells expressing mutant EGFR. Also inhibits MST1 (IC50 = 37.7 nM). Orally bioavailable.

Specifications

Chemical Name or Material (2 E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
CAS 698387-09-6
Quantity 10 mg
Target EGF Receptor Inhibitors
Molecular Formula C30H29ClN6O3
Purity 0.98