missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 61545

Tocris Bioscience™ MZ 1

Catalog No. 61545
Change view
Click to view available options
Quantity:
5 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
61545 5 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. 61545 Supplier Tocris Bioscience™ Supplier No. 6154/5
Only null left

Description

(+)-JQ1 based Degrader (PROTAC™) that selectively degrades BRD4

Cell penetrant Degrader (PROTAC®) compound based on (+)-JQ1 (Cat.No. 4499) conjugated to a von Hippel-Lindau (VHL) ligand. MZ 1 retains high affinity for BRD2, BRD3 and BRD4 bromodomains (Kd = 13-60 nM) but induces preferential degradation of BRD4 over BRD2 and BRD3 (DC50 values for degradation of BRD4 are 8 and 23 nM in H661 and H838 cells, respectively). Exhibits potent cytotoxicity and antiproliferative effects in AML cell lines (pEC50 = 7.6 in Mv4-11 cells).

Negative control cis MZ 1 also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

CAS 1797406-69-9
Quantity 5 mg
Target Bromodomain
Molecular Formula C49H60ClN9O8S2
Formula Weight 1002.64g/mol
Product Type Cell Degrader

For Research Use Only