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  5. 80735

Tocris Bioscience™ MS 6105

Catalog No. 80735
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Catalog No.
80735 5 mg
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Catalog No. 80735 Supplier Tocris Bioscience™ Supplier No. 8073/5
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Description

Potent lactate dehydrogenase Degrader (PROTAC™)

MS 6105 is a potent and selective lactate dehydrogenase (LDH) Degrader (PROTAC™; for LDHA and LDHB respectively, DC50 values are 38 nM and 74 nM; Dmax is 93% and 86%). Comprises an LDH inhibitor warhead connected by a linker to a VHL ligand. Suppresses growth of several pancreatic cancer cell lines (IC50 range is 12.2 μM - 16.1 μM). Bioavailable in vivo.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 2-(5-(Cyclopropylmethyl)-3-(3-(6-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridecanamido)hex-1-yn-1-yl)phenyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-ca
CAS 2891709-58-1
Quantity 5 mg
Target Active Degraders
Molecular Formula C65H81N9O9S3
Purity 98%