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Tocris Bioscience™ MS 275

Catalog No. 620810
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620810 10 mg
620850 50 mg
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Catalog No. 620810 Supplier Tocris Bioscience™ Supplier No. 6208/10

Description

HDAC (Class I) inhibitor

MS 275 is a class I HDAC inhibitor (IC50 values are 0.18, 0.74, 44.9 and >100 μM for HDAC1, 3, 8 and 6, respectively). Exhibits antiproliferative effects and induces apoptosis in a range of tumor cell lines in vitro and in vivo. Increases estrogen receptor α- and aromatase expression in breast cancer cells. Inhibits PCB-induced neuronal cell death by preventing HDAC3 binding and histone deacetylation within the synapsin-1 promoter.

Specifications

Chemical Name or Material (Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate
CAS 209783-80-2
Assay Percent Range >99%
Quantity 10 mg
Molecular Formula C21H20N4O3
Formula Weight Observed MW: 376.41