Thapsigargin is a naturally occurring sesquiterpene lactone isolated from the umbelliferous plant Thapsia garganica. This tumor promoter releases Ca2++ from intracellular stores by specifically inhibiting the endoplasmic reticulum Ca2++-ATPase. It does not directly affect plasma membrane Ca2++-ATPases, Ins 1,4,5-P3 production or protein kinase C activity.
Cell Analysis, Cell Structure, Cellular Imaging, Immunofluorescence (IF), Immunofluorescence Staining and Detection, Receptors
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