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Tocris Bioscience™ ML T7

Catalog No. 811950
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50 mg
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Catalog No. Quantity
811950 50 mg
811910 10 mg
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Catalog No. 811950 Supplier Tocris Bioscience™ Supplier No. 8119/50
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Description

Inhibitor of phosphatidylserine/CEACAM1 binding to Tim-3

ML T7 is a T cell immunoglobulin and mucin-containing molecule 3 (Tim-3) inhibitor; disrupts phosphatidylserine/CAECAM1 binding to Tim-3 (Kd = 7.0 μM and 7.4 μM for hTim-3 and mTim-3 respectively). ML T7 promotes cell proliferation, cytokine production and cytotoxicity of OT-I CD8+ cytotoxic T lymphocytes. ML T7 inhibits tumor growth in a syngeneic mouse model of hepatocellular carcinoma, increases NK cell tumor killing activity and DC maturation.

Specifications

Chemical Name or Material 5-(2,4-Dichlorophenyl)-3a,6a-dihydro-3-(4-methylphenyl)spiro[1H-furo[3,4-c]pyrrole-1,2'-[2H]indene]-1',3',4,6(3H,5H)-tetrone
CAS 459789-75-4
Quantity 50 mg
Target CEACAM1/CD66a
Molecular Formula C27H17Cl2NO5
Purity 0.98