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Tocris Bioscience™ ML 162

Catalog No. 782110
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50 mg
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Catalog No. Quantity
782110 10 mg
361063837 50 mg
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Catalog No. 782110 Supplier Tocris Bioscience™ Supplier No. 7821/10

Description

Inhibits glutathione peroxidase (GPX4); induces ferroptosis

ML 162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. It induces ferroptosis in vivo. It is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50 = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

Specifications

Chemical Name or Material 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide
CAS 1035072-16-2
Quantity 10 mg
Target Glutathione Peroxidase 4/GPX4
Molecular Formula C23H22Cl2N2O3S
Purity 0.98