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Methotrexate disodium salt, 98.5%

Catalog No. AAJ66364MD
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AAJ66364MD 250 mg
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Catalog No. AAJ66364MD Supplier Thermo Scientific Chemicals Supplier No. J66364MD
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Description

Methotrexate disodium salt, CAS # 7413-34-5, is the sodium salt of methotrexate that shows antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities. | CAS: 7413-34-5 | C20H20N8Na2O5 | 498.411 g/mol

Inhibits the metabolism of folic acid

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Methotrexate disodium salt is an organic sodium salt derived from methotrexate with antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities

• It acts as an enzyme inhibitor of dihydrofolate reductase

• It binds to and inhibits purine nucleotide and thymidylate synthesis, leading to the inhibition of DNA and RNA synthesis. Because of this mechanism of action, the methotrexate disodium salt is defined as a nucleic acid synthesis inhibitor

Application

• Methotrexate disodium salt is a folic acid antagonist with the ability to inhibit folic acid metabolism

• In vitro studies demonstrated that methotrexate disodium salt has potent activity against pyrimethamine-resistant Plasmodium vivax malaria parasites

• This compound has been used in chimeric polymersomes in order to investigate its effect in lung tumor xenografts in mice

Chemical Identifiers

CAS 7413-34-5
Molecular Formula C20H20N8Na2O5
Molecular Weight (g/mol) 498.411
MDL Number MFCD00274560
InChI Key DASQOOZCTWOQPA-GXKRWWSZSA-L
Synonym methotrexate disodium salt, sodium methotrexate, ledertrexate, methotrexate sodium, mtx disodium, methotrexate disodium, unii-3ig1e710zn, trexall, mexate, methotrexate lpf
PubChem CID 11329481
ChEBI CHEBI:50679
IUPAC Name disodium;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
SMILES CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

Specifications

Color Yellow
Boiling Point 823°C
Quantity 250 mg
UN Number UN2811
Sensitivity Hygroscopic
Solubility Information Soluble in water
Formula Weight 498.4
Percent Purity 98.5%
Physical Form Powder
Chemical Name or Material Methotrexate disodium salt

Safety and Handling

Hazard Category H301-H315-H319
Hazard Statement GHS H Statement
H301
Toxic if swallowed.
Precautionary Statement P264b-P270-P280-P301+P310-P302+P352-P305+P351+P338-P330-P332+P313-P362-P501c
DOTInformation Hazard Class: 6.1
EINECSNumber 231-022-0
RTECSNumber MA1232000
TSCA No
storageNote1 2° to 8°C
Recommended Storage Keep cold; Store under Argon

RUO – Research Use Only