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Tocris Bioscience™ Lestaurtinib

Catalog No. 33951
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Catalog No. Quantity
33951 1 mg
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Catalog No. 33951 Supplier Tocris Bioscience™ Supplier No. 3395/1

Description

JAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB

Potent JAK2, FLT3 and TrkA inhibitor (IC50 values are 0.9, 3 and < 25 nM, respectively). Also inhibits Aurora kinase A and B (IC50 values are 8.1 and 2.3 nM, respectively) and prevents STAT5 phosphorylation (IC50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo.

Chemical Identifiers

CAS 111358-88-4
Molecular Formula C26H21N3O4

Specifications

Quantity 1 mg
Formula Weight 439.46
Purity >99%
Molecular Weight (g/mol) 439.47
Chemical Name or Material Lestaurtinib

Safety and Handling

Recommended Storage Desiccate at -20°C