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Tocris Bioscience™ LEI 401

Catalog No. 740710
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740710 10 mg
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Catalog No. 740710 Supplier Tocris Bioscience™ Supplier No. 7407/10*
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Description

High affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor

LEI 401 is a high affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor (Ki = 0.027 and 0.18 μM for human and mouse NAPE-PLD, respectively; IC50 for human enzyme = 0.86 μM). LEI 401 exhibits no significant activity at cannabinoid receptors or other metabolic enzymes of the endocannabinoid system. The product reduces levels of N-acylethanolamines (NAE) in a neuroblastoma cell line in vitro. It also reduces anandamide levels in mouse brain in vivo and impairs fear extinction. LEI 701 is CNS penetrant and cell-permeable.

Specifications

Chemical Name or Material N-(Cyclopropylmethyl)-6-[(3 S)-3-hydroxy-1-pyrrolidinyl]-2-[(3 S)-3-phenyl-1-piperidinyl]-4-pyrimidinecarboxamide
CAS 2393840-15-6
Quantity 10 mg
Target Phospholipase Inhibitors
Molecular Formula C24H31N5O2
Purity 0.98