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Tocris Bioscience™ Indinavir sulfate

Catalog No. 719650
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50 mg
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Catalog No. Quantity
719650 50 mg
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Catalog No. 719650 Supplier Tocris Bioscience™ Supplier No. 7196/50
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Description

Potent and selective HIV-1 and HIV-2 protease inhibitor

Indinavir sulfate is a potent and selective HIV protease inhibitor (Ki values are 0.52 and 3.3 nM for HIV-1 and HIV-2, respectively). Indinavir stops the spread of the HIV-infected MT4 lymphoid cells at concentrations of 25-50 nM. Indinavir disrupts the ERK1/2 and p38 MAPK pathways and reduces both the level of functional eIF4F complex and rpS6 phosphorylation, which leads to a decrease in protein synthesis in mouse myocytes. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CLpro.

Specifications

Chemical Name or Material 2,3,5-Trideoxy-N-[(1 S,2 R)-2,3-dihydro-2-hydroxy-1 H-inden-1-yl]-5-[(2 S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate
CAS 157810-81-6
Quantity 50 mg
Target HIV Protease Inhibitors
Molecular Formula C36H47N5O4.H2SO4
Purity 0.98