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  5. Tocris Bioscience™ Hydroxychloroquine sulfate

Tocris Bioscience™ Hydroxychloroquine sulfate

Catalog No. 564810
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564810 10 mg
564850 50 mg
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Catalog No. 564810 Supplier Tocris Bioscience™ Supplier No. 5648/10
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Description

Autophagy inhibitor; also TLR9 inhibitor

Autophagy inhibitor. Inhibits growth and induces apoptosis of renal cancer cells in vitro. Also inhibits TLR9. Additionally inhibits PRC2 by inhibiting the allosteric binding of PRC2 to EED (embryonic ectoderm development) within the H3K27me3-binding pocket, and reduces H3K27me3 levels in multiple myeloma cells in vitro.

Hydroxychloroquine sulfate is an autophagy inhibitor. Also inhibits TLR9. Inhibits growth and induces apoptosis of renal cancer cells in vitro. Additionally inhibits PRC2 by inhibiting the allosteric binding of PRC2 to EED (embryonic ectoderm development) within the H3K27me3-binding pocket, and reduces H3K27me3 levels in multiple myeloma cells in vitro. Inhibits SARS-CoV-2 viral infection, in vitro (EC50 values in μM range and dependent on viral RNA copy number). Hydroxychloroquine improves efficacy of adeno-associated viral gene transduction in vivo and in vitro. Also antimalarial and immunomodulator. Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Specifications

Chemical Name or Material 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate
CAS 747-36-4
Quantity 10 mg
Target Autophagy-related Compounds
Molecular Formula C18H28ClN3O5S
Formula Weight 433.95
Purity >99%