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Gibco™ Human Myostatin Propeptide Recombinant Protein, PeproTech®
Recombinant Protein
Supplier: Gibco™ 12012250UG
Description
Recombinant Human Myostatin-Propeptide is a 27.8 kDa protein consisting of 244 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Mature myostatin is obtained by proteolytic processing of a biologically-inactive precursor protein, which contains an N-terminal propeptide of 243 amino acid residues. Myostatin-Propeptide exhibits high binding affinity for myostatin, and has been shown to be a potent inhibitor of myostatin. Over-expression of myostatin-propeptide in mice resulted in large increases (up to 200%) in skeletal muscle mass, similar to those observed in myostatin knockout mice.Specifications
| O14793 | |
| protein with no preservative | |
| 27.8 kDa | |
| 250 μg | |
| RUO | |
| Myostatin | |
| MSTN | |
| Unconjugated | |
| MNENSEQKEN VEKEGLCNAC TWRQNTKSSR IEAIKIQILS KLRLETAPNI SKDVIRQLLP KAPPLRELID QYDVQRDDSS DGSLEDDDYH ATTETIITMP TESDFLMQVD GKPKCCFFKF SSKIQYNKVV KAQLWIYLRP VETPTTVFVQ ILRLIKPMKD GTRYTGIRSL KLDMNPGTGI WQSIDVKTVL QNWLKQPESN LGIEIKALDE NGHDLAVTFP GPGEDGLNPF LEVKVTDTPK RSRR | |
| E. coli | |
| ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Functional Assay | |
| 2660 | |
| Human Myostatin Propeptide | |
| E. coli | |
| <1 EU/ μg | |
| pro-Myostatin | |
| Determined by its ability to neutralize the Myostatin inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.01-0.04 ug/ml in the presence of 50 ng/ml Myostatin. | |
| Recombinant | |
| -20°C | |
| Lyophilized |