Applied Biosystems™ Human Alzheimer's Array

Description

• Two TaqMan™ Alzheimer’s Arrays are available: one for human and one for mouse
• The mouse assays closely follow the human panel and are from orthologous genes of the human assays
  • The human panel contains 94 test assays and two endogenous controls (18S and HPRT1)
  • The mouse panel has 92 assays and four controls (18S, actb, hprt1 and ipo8)
• Each card contains a select group of TaqMan™ Gene
• Expression Assays pre-configured in a micro fluidic array, ready to ship
• TaqMan™ Arrays are available in economical four-card packages that enable users to simplify their workflow without breaking the budget
• Consistent, reliable data across samples, studies, and labs

The Right Targets

• TaqMan™ Gene Expression Assays for the Alzheimer’s TaqMan™ Array were based on the 'amyloid hypothesis’
• Genes were selected that are involved in APP processing that generate Aβ and included genes implicated in multiple secondary steps of Aβ aggregation, tau hyperphosphorylation, excitotoxicity, inflammation, oxidation and microglial activation
• Assays were also added for genes involved in cholesterol biosynthesis because of the correlation between high cholesterol and increased risk of AD3
• Numerous reports of genes associated with AD pathology, biochemistry and genetics are also included

Easy to Load and Run

• Using the TaqMan™ array is fast and simple
• The micro fluidic technology uses 8 sample-loading ports, each connected to 48 reaction wells
• Simply pipette a sample (pre-mixed with TaqMan™ Universal PCR Master Mix) into each sample-loading port and briefly centrifuge
• Within minutes, the 384-well TaqMan™ array is ready to run on the 7900HT Fast Real-Time PCR System

Ideal Screening Technology

• TaqMan™ Arrays are ideal for researchers' screening applications, from biomarker and toxicology screens to pathway and disease-set analysis
• These arrays are part of a collection of TaqMan™ Arrays that enable analysis of hundreds of TaqMan™ Gene Expression Assays on an array with minimal effort
• TaqMan™ Gene Expression Assays are preloaded so users can standardize samples and laboratory sites while maintaining reproducibility, accuracy, and sensitivity