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Tocris Bioscience™ GRL 0617

Catalog No. 728025
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25 mg
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Catalog No. Quantity
728025 25 mg
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Catalog No. 728025 Supplier Tocris Bioscience™ Supplier No. 7280/25

Description

Coronavirus PLpro inhibitor

GRL 0617 is a coronavirus papain-like protease (Plpro) inhibitor (IC50 values are 0.6 and 0.8 μM for SARS-COV and SARS-CoV-2 PLpro, respectively). Inhibits deubiquitination activity of SARS-CoV PLpro. Displays no inhibition of human deubiquitinating enzymes. Improves cell viability following SARS-CoV infection. Inhibits SARS-CoV-2 viral replication and induces antiviral immune signaling pathways following SARS-CoV-2 infection in CaCo-2 cells.

Specifications

Chemical Name or Material 5-Amino-2-methyl-N-[(1 R)-1-(1-naphthalenyl)ethyl]benzamide
CAS 1093070-16-6
Quantity 25 mg
Target Papain-like Protease Inhibitors
Molecular Formula C20H20N2O
Purity 0.98