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Tocris Bioscience™ GNF 5837

Catalog No. 455910
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50 mg
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Catalog No. Quantity
455910 10 mg
455950 50 mg
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Catalog No. 455910 Supplier Tocris Bioscience™ Supplier No. 4559/10

Description

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 μM respectively). Orally bioavailable.

Chemical Identifiers

CAS 1033769-28-6
Molecular Formula C28H21F4N5O2

Specifications

Quantity 10 mg
Formula Weight 535.49
Purity >98%
Molecular Weight (g/mol) 535.50
Chemical Name or Material GNF 5837

Safety and Handling

Recommended Storage Store at +4°C