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Tocris Bioscience™ Gefitinib-based PROTAC™ 3

Catalog No. 72585
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72585 5 mg
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Catalog No. 72585 Supplier Tocris Bioscience™ Supplier No. 7258/5
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Description

Potent EGFR PROTAC™

Gefitinib-based PROTAC® 3 is a potent EGFR PROTAC™ Degrader. Comprises an EGFR inhibitor gefitinib (Iressa Cat.No. 3000) conjugated to a VHL ligand via a linker. Induces EGFR degradation (DC50 values are 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively). Exhibits no degradation of wild-type EGFR at concentrations up to 10 μM.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material (2 S,4 R)-1-(-2-(3-(2-((5-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS 2230821-27-7
Quantity 5 mg
Target Active Degraders
Molecular Formula C47H57ClFN7O8S
Purity 0.98