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Thermo Scientific™ Dynabeads™ CaptureSelect™ AAVX Magnetic Beads
Thermo Scientific™ Dynabeads™ CaptureSelect™ AAVX Magnetic Beads are high-capacity, high-throughput magnetic affinity particles for the purification of a broad range of naturally occurring and synthetic adeno-associated virus (AAV) serotypes used for gene therapy applications.
$1293.88 - $22293.50
Specifications
| Binding Capacity | ∼1 x 1012 viral particles/mg beads |
|---|---|
| Concentration | 30 mg beads/mL slurry, 1 mg contains approximately 1.3 x 107 beads |
| Formulation | Tris-buffered saline with 0.05% Tween-20 and 0.05% Sodium Azide |
| Matrix | Non-porous monodisperse superparamagnetic beads |
| Content And Storage | Store at 2–8°C. |
| Catalog Number | Mfr. No. | Capacity (Metric) | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Capacity (Metric) | Price | Quantity | |||||
|
28-535-22001
|
Thermo Scientific™
2853522001 |
1 mL |
Each for $1,293.88
|
|
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|
28-535-22005
|
Thermo Scientific™
2853522005 |
5 mL |
Each for $3,886.15
|
|
|||||
|
28-535-22050
|
Thermo Scientific™
2853522050 |
50 mL |
N/A
|
N/A | |||||
| Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance. | |||||||||
Description
Dynabeads CaptureSelect AAVX Magnetic Beads are high-capacity, high-throughput magnetic affinity particles for the purification of a broad range of naturally occurring and synthetic adeno-associated virus (AAV) serotypes used for gene therapy applications. The anti-AAVX affinity ligand demonstrates good binding reactivity towards a large variety of AAV serotypes, including AAV1 to AAV8, AAVrh10, and synthetic serotypes. The magnetic beads enable purification using manual and robotic magnetic separators of AAV serotypes directly from crude feedstock in a single step with high purity and yield.
Features of DynaBeads CaptureSelect AAVX Magnetic Beads include:
- One-magnetic-step AAV purification from crude material with high purity and yield
- Compatible with manual and automated workflows
- High specificity and capacity
- Easy upscaling to higher volumes
- Non-animal derived
Animal origin statement
CaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (VHH) created by a proprietary technology. The VHH affinity ligand is a ∼12–15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain, efficiently produced in yeast Saccharomyces cerevisiae by a production process free of any animal components (Animal Origin-Free).
Main characteristics
- Bead matrix: superparamagnetic
- Bead size: 4.5 μm
- Ligand: CaptureSelect AAVX affinity ligand
- Binding capacity: ∼1 x1012 viral particles/mg beads
- Elution conditions: 50 mM citric acid pH 2.5-3.0
- Formulation buffer: tris-buffered saline, 0.05% Tween 20, 0.05 % sodium azide
Specifications
| ∼1 x 1012 viral particles/mg beads | |
| Tris-buffered saline with 0.05% Tween-20 and 0.05% Sodium Azide | |
| Store at 2–8°C. | |
| Resin Slurry | |
| Magnetic isolation of AAV capsids | |
| AAVX Affinity Ligand |
| 30 mg beads/mL slurry, 1 mg contains approximately 1.3 x 107 beads | |
| Non-porous monodisperse superparamagnetic beads | |
| 4.5 μm | |
| CaptureSelect | |
| Multiple AAV serotypes |