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  8. Dobutamine hydrochloride

Dobutamine hydrochloride

Catalog No. AAJ61333MD
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Quantity:
1 g
250 mg
Catalog No. Quantity
AAJ61333MD 250 mg
AAJ6133303 1 g
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Catalog No. AAJ61333MD

Supplier: Thermo Scientific Chemicals J61333MD

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Description

CAS: 49745-95-1 | C18H24ClNO3 | 337.84 g/mol

Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1M.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 μM.

Solubility
Soluble in water or ethanol with warming. Also soluble in methanol

Notes
Solutions oxidize readily at pH greater than 11. Protect solutions from light

Chemical Identifiers

CAS 49745-95-1
Molecular Formula C18H24ClNO3
Molecular Weight (g/mol) 337.84
MDL Number MFCD00153795
InChI Key BQKADKWNRWCIJL-UHFFFAOYNA-N
Synonym dobutamine hydrochloride, dobutamine hcl, dobutrex, inotrex, dl-dobutamine hydrochloride, dobutamina clorhidrato spanish, 4-2-4-4-hydroxyphenyl butan-2-ylamino ethyl benzene-1,2-diol hydrochloride, +--4-2-3-p-hydroxyphenyl-1-methylpropyl amino ethyl pyrocatechol hydrochloride, 1,2-benzenediol, 4-2-3-4-hydroxyphenyl-1-methylpropyl amino ethyl-, hydrochloride, +-
PubChem CID 65324
ChEBI CHEBI:4671
IUPAC Name hydrogen 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol chloride
SMILES [H+].[Cl-].CC(CCC1=CC=C(O)C=C1)NCCC1=CC=C(O)C(O)=C1

Specifications

Melting Point 184°C to 186°C
Color White
Quantity 250 mg
Merck Index 14,3395
Solubility Information Soluble in water or ethanol with warming; Also soluble in methanol
Formula Weight 337.85
Physical Form Powder
Chemical Name or Material Dobutamine hydrochloride

Safety and Handling

Hazard Category H302+H312+H332-H361
Hazard Statement GHS H Statement
H361-H302-H312-H332
Suspected of damaging fertility or the unborn child.
Harmful if swallowed.
Harmful in contact with skin.
Harmful if inhaled.
Precautionary Statement P201-P202-P261-P264b-P270-P271-P281-P301+P312-P302+P352-P304+P340-P308+P313-P312-P330-P363-P501c
EINECSNumber 256-464-1
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only