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Tocris Bioscience™ Dacomitinib

Catalog No. 623110
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623110 10 mg
623150 50 mg
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Catalog No. 623110 Supplier Tocris Bioscience™ Supplier No. 6231/10
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Description

Potent irreversible pan ErbB inhibitor

Dacomitinib is a potent irreversible pan ErbB inhibitor (IC50 values are 6.0, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively). Inhibits mutant and wild type forms of ErbB, including EGFR T780M, and shows activity in NSCLC cell lines sensitive and resistant to Iressa (Cat. No. 3000). Inhibits tumor growth. Orally bioavailable.

Specifications

Chemical Name or Material (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
CAS 1110813-31-4
Assay Percent Range >98%
Quantity 10 mg
Molecular Formula C24H25ClFN5O2
Formula Weight Observed MW: 469.94