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Tocris Bioscience™ Compound E

Catalog No. 64761
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64761 1 mg
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Catalog No. 64761 Supplier Tocris Bioscience™ Supplier No. 6476/1*
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Description

γ-secretase inhibitor; induces neuronal differentiation

Compound E is a γ-secretase and notch patchway inhibitor. Compound E enhances growth inhibition, differentiation and migration of neuroblastoma cells when used in a combination with DAPT (Cat. No. 2634) and 13-cis RA. In combination with hLIF, CHIR 99021 (Cat. No. 4423) and SB 431542 (Cat. No. 1614), Compound E accelerates the induction of a homogeneous, self-renewing primitive neuroepithelium population from hESCs. Compound E is active in vitro and in vivo.

For more information about how Compound E may be used, see our protocol:

Generation of β cells from hPSCs

Specifications

Chemical Name or Material N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
CAS 209986-17-4
Quantity 1 mg
Molecular Formula C27H24F2N4O3
Purity 98%