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  5. Tocris Bioscience™ CGI 1746

Tocris Bioscience™ CGI 1746

Catalog No. 696510
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Quantity:
10 mg
50 mg
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Catalog No. Quantity
696510 10 mg
696550 50 mg
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Catalog No. 696510 missing translation for 'mfr' Tocris Bioscience™ missing translation for 'supplierNo' 6965/10

Description

Potent, reversible BTK inhibitor

CGI 1746 is a potent, reversible inhibitor of Bruton's tyrosine kinase (Btk) (IC50 = 1.9 nM). CGI 1746 decreases cell survival in prostate cancer cell lines. In a cell model, CGI 1746 blocks the production of FcγR-induced cytokines IL-1β, TNFα and IL-6 (IC50 values are 36 nM, 47 nM and 353 nM, respectively).

Specifications

Chemical Name or Material N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)benzamide
CAS 910232-84-7
Quantity 10 mg
Target Brutons Tyrosine Kinase (BTK) Inhibitors
Molecular Formula C34H37N5O4
Purity 0.97